In Canada, 16,000 persons are living with early-onset dementia (EOD) (Alzheimer Society Canada, 2016). Several studies have described that the diagnosis of EOD lead to difficulties for the couple and in particular for spouse caregiver who must face many challenges and deal with new roles. Yet, little is known about the transitions experienced by these caregivers beyond the diagnosis period. The purpose of this descriptive qualitative study was to explore the perceptions of the transitions experienced by the spouse caregiver of people with EOD whose diagnosis has been established for more than two years. More specifically, it aims to describe the types of transitions experienced by the spouse caregivers, the conditions that facilitate and inhibit the “success” of the transitions as well as the response patterns identified by the spouse caregivers. The theory of transitions of Meleis et al. (2000) was used as framework. Semi-structured interviews were conducted with three caregivers. A thematic analysis according to Paillé and Mucchielli (2016) brought out three themes: 1) a long journey of caregiving marked out by multiple transitions; 2) personal and community conditions that influence the success of multiple transitions and 3) a variety of strategies for coping with the caregiver role. The results of this study help better understand the lived experience by spouse caregivers and could guide nurses in assessing the specific needs of caregivers, as well as the development of interventions and services that can facilitate various transitions. Further studies will be needed to understand the caregiving experience of spouse living with a partner diagnosis with EOD. Directions for research, practice and nursing education are presented.