Around the world, the COVID-19 pandemic has generated clinical challenges for health personnel in general and hospital personnel in particular. In Mexico, the clinical psychologists who are part of the local hospital systems have adapted professional practices to provide mental health care in COVID-19 frontline hospitals. This text describes the actions and challenges arising from treating patients, families, and health workers in six COVID-19 hospitals in Mexico. It highlights the main problems identified, strategies to address them, and the barriers encountered during this pandemic. Finally, this document may be useful for planning clinical psychological activities within COVID-19 hospitals in places where new waves of contagion appear.