Large-scale in silico scientific experiments generally contain multiple computational activities to process big data. Scientific Workflows (SWfs) enable scientists to model the data processing activities. Since SWfs deal with large amounts of data, data-intensive SWfs is an important issue. In a data-intensive SWf, the activities are related by data or control dependencies and one activity may consist of multiple tasks to process different parts of experimental data. In order to automatically execute data-intensive SWfs, Scientific Work- flow Management Systems (SWfMSs) can be used to exploit High Performance Computing (HPC) environments provided by a cluster, grid or cloud. In addition, SWfMSs generate provenance data for tracing the execution of SWfs.Since a cloud offers stable services, diverse resources, virtually infinite computing and storage capacity, it becomes an interesting infrastructure for SWf execution. Clouds basically provide three types of services, i.e. Infrastructure-as-a-Service (IaaS), Platform- as-a-Service (PaaS) and Software-as-a-Service (SaaS). SWfMSs can be deployed in the cloud using Virtual Machines (VMs) to execute data-intensive SWfs. With a pay-as-you- go method, the users of clouds do not need to buy physical machines and the maintenance of the machines are ensured by the cloud providers. Nowadays, a cloud is typically made of several sites (or data centers), each with its own resources and data. Since a data- intensive SWf may process distributed data at different sites, the SWf execution should be adapted to multisite clouds while using distributed computing or storage resources.In this thesis, we study the methods to execute data-intensive SWfs in a multisite cloud environment. Some SWfMSs already exist while most of them are designed for computer clusters, grid or single cloud site. In addition, the existing approaches are limited to static computing resources or single site execution. We propose SWf partitioning algorithms and a task scheduling algorithm for SWf execution in a multisite cloud. Our proposed algorithms can significantly reduce the overall SWf execution time in a multisite cloud.In particular, we propose a general solution based on multi-objective scheduling in order to execute SWfs in a multisite cloud. The general solution is composed of a cost model, a VM provisioning algorithm, and an activity scheduling algorithm. The VM provisioning algorithm is based on our proposed cost model to generate VM provisioning plans to execute SWfs at a single cloud site. The activity scheduling algorithm enables SWf execution with the minimum cost, composed of execution time and monetary cost, in a multisite cloud. We made extensive experiments and the results show that our algorithms can reduce considerably the overall cost of the SWf execution in a multisite cloud.