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ID: <

10670/1.81q08l

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DOI: <

10.26226/morressier.5d5e5188bedcf39b7665276b

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P4-06-02 - Relationship of obesity with B vitamin status: analysis of NDNS data from UK women of reproductive age

Abstract

Relationship of obesity with B vitamin status: analysis of NDNS data from UK women of reproductive age Kerr M.A1, Livingstone M.B.E1, Ward M1, McAnena L1, Cox L2, Price R.K1, Pentieva K1 and McNulty H11 Nutrition Innovation Centre for Food and Health, Ulster University Northern Ireland2 Medical Research Council, Elsie Widdowson Laboratory, Cambridge UKPre-pregnancy obesity is associated with a 2-fold increased risk of Neural Tube Defects (NTD), an effect not explained by lower dietary folate intake, or non-use of folic acid supplements (as recommended globally to women before and in early pregnancy for NTD prevention). While the exact mechanism linking NTD and obesity is poorly understood, it is possible that a compromised status or metabolism of folate and/or of the closely related micronutrients (vitamin B12, B6 and riboflavin) may be involved. To date however, this hypothesis has not been adequately explored. This study therefore aimed to investigate the relationship of obesity with folate and related B vitamin biomarkers in a representative cohort of non-pregnant UK women of reproductive age. Data were accessed from the most recent UK National Diet and Nutrition Survey (NDNS; Years 7-8; 2015-16), a rolling cross-sectional survey designed to gather information from a representative sample of the UK population on nutrient intakes, food consumption and nutritional status. Data for women aged 16-45 years (non B vitamin supplement users; n 602), were extracted on: anthropometry (height, weight, body mass index [BMI] and waist circumference [WC]), dietary intakes of B vitamins and biomarkers for folate (serum and red blood cell (RBC) folate), vitamin B12 (total serum B12 and serum holotranscobalamin [holoTC]), vitamin B6 (plasma pyridoxal-5-phosphate [PLP]) and riboflavin (erythrocyte glutathione reductase activation coefficient [EGRac]). Prevalence of overweight and obesity (i.e. BMI: 25-30kg/m2 and >30kg/m2) was 30% and 22% respectively, whilst abdominal obesity (i.e. WC >88cm) was present in 34% of the women. No significant correlations were observed between either BMI or WC and biomarker status of folate (RBC and serum folate), vitamin B12 (total serum B12 and serum holoTC) or riboflavin (EGRac). However vitamin B6 status (PLP concentration) was negatively correlated with both BMI and WC (r -0.272, P 0.002 and r-0.362; P 0.029, respectively). No significant differences were observed between lean and obese women in biomarker status of folate (RBC* and serum folate*), vitamin B12 (total serum B12 and serum HoloTC*) or riboflavin (EGRac). However Vitamin B6 status was significantly lower among the obese women compared with the lean women (37.9nol.L v 30.6nmol/L; P 0.017). No differences in B vitamin dietary intake were observed by categories of abdominal obesity. Abdominal obesity may be a risk factor for low status of vitamin B6, independently of dietary intake. Based on these preliminary findings, the current research cannot confirm the relationship of folate or vitamin B12 with obesity, however further analysis is required.*Analysis is preliminary as biomarker data are currently incomplete

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