The interglacial period, known as Marine Isotope Stage 11 (MIS 11, 428-397 thousand years ago), is often consideredas a potential analogue for future climate projection because of the similar patterns of insolation variability.However, studies on mechanisms of the onset of MIS 11 (called Termination V, T-V) in response to insolationincrease is still hampered by a lack of good dating materials in paleoclimate archives, despite a stack of East Asianmonsoon records with precise U-Th dates has been proposed. Previous studies suggested the 18O value registeredin speleothems in Mediterranean realm can be a good bridge connecting the U-Th-based age model of speleothemto marine cores from Mediterranean sea, which opens a new possibility to detect ocean-atmosphere/internalexternalforcing interaction beyond 14C dating limitation. Here we present a new speleothem 18O record fromnorthern Italy covering 500-300 thousand years ago. The results show a similar pattern with 18O records ofmarine cores around Mediterranean. The age model of the speleothem hence provides an opportunity for tuningthe marine cores, which could improve our understanding of relationship between global atmosphere and oceancirculations.