The myocardium is considered the most important tissue in the heart, which has the ability to contract and relax in response to intrinsic and extrinsic stimuli, it is anatomic surrounded by a capillary vascular network that irrigates it continuously carrying nutrients and oxygen and also serves to eliminate waste products from the tissue. It is important to avoid damage to the myocardium caused by ischemia-reperfusion processes to reduce functional, physiological and clinical complications. Damage to the myocardium is time-dependent of ischemia, prolonged ischemia can exert irreversible effects. Myocardial ischemia occurs when the vascular blood flow in the heart is partially or totally blocked, resulting in damage due to lack of oxygen and nutrients and the accumulation of carbon dioxide. Ischemia leads to a decrease in the contractile capacity of the heart and its function as a pump, negatively affecting the quality of life of the patient. Myocardial ischemia is associated with high mortality. The use of medicinal plants in the treatment of diseases dates from ancient times and medicinal plants are still widely used today. Matricaria recutita is a plant used to treat anxiety, digestive problems, diarrhea, colic, antiparasitic and antioxidant activity due to its metabolites. Matricaria recutita is an 20 to 50 cm herb with origin from Europe and Asia and was introduced in many countries among them in Mexico. There are few reports in the literature that show the cardioprotective effect of Matricaria recutita. In the present study the objective was to evaluate the cardioprotective effect of a hydroalcoholic extract (50:50 water-alcohol) of leaves, stems and flowers of Matricaria recutita against the damage caused by a total ischemia of 10 minutes and subsequent reperfusion, measuring under different coronary flow vascular contraction, ventricular contractility and electrical conduction. To carry out the project, the leaves, stems and flowers of Matricaria recutita were obtained, ground and weighed 200 grams to undergo maceration for 5 days in a 50% methanol and 50% water solution. Afterwards, the extract was filtered and rotavapor was used to concentrate it, to finally store it at 4 °C for its later use. Wistar rats were administered with the hydroalcoholic extract of Matricaria recutita orally at a dose of 0.5 mg/kg during 15 days, in this time the rats were weighed and observed continuously. After the treatment period with the extract the rats were sacrificed by means of an administration of sodium pentobarbital and heparin. The heart of each animal was extracted and placed in the isolated heart system under the Langendorff technique. The responses of the initial tissue before and after a total ischemia of 10 minutes and subsequent reperfusion were evaluated at three different flows 8, 10 and 12 ml / min. The responses were coronary perfusion pressure as the variable indicating vascular contraction, ventricular contraction and electrical activity measured as atrio-ventricular delay. No significant differences were found between the responses of the hearts of control or treated rats with the extract of the plant before ischemia. In contrast, the responses after ischemia of the hearts treated with the hydroalcoholic extract of Matricaria recutita were statistically higher when the control group was compared. The results indicate that the pretreatment with hydroalcoholic extract of Matricaria recutita improves the vascular and ventricular contractile response as well as electrical after ischemia and reperfusion. The above suggests cardioprotection due to the consumption of hydroalcoholic extract of Matricaria recutita.