Receptors of Fc of Immunoglobulin G (FcγR) are involved in many immune responses. Two low affinity groups exist: FcγRIIa/b/c, and FcγRIIIa/b, FcγRIIb is the only inhibitor. Several polymorphisms, altering the affinity ligand and receptor response, are selected by an infectious pressure and associated with autoimmune diseases (AID). We studied the association of polymorphisms FcγRIIa-R131H, FcγRIIb-I232T, FcγRIIIa-F158V, FcγRIIIb-Na1/Na2 to systemic lupus erythematosis (SLE), neuromyelitis optica (NMO) and multiple scelrosis (MS) in Martinique. Our results show a high frequency of alleles T232, V158 and 232TT and 158VV genotypes in Martinican, an increase in the frequency of the homozygous Na1, Na1 and 158F alleles in SLE, an increase of 131RR genotype, the 131R and 158V alleles in SLE with kidney disease, an increase of 131RR genotype and a decrease of NA2 / NA2 in MS but an increase in the 232T allele in NMO. Study of the influence of FcγRIIb-I232T on the activation of the B cells receptor (BCR) in lupus and healthy controls controls exibiting IT, TT or II forms, shows that the regulation of BCR is effective even in the presence TT form. These results show for the first time Martinican population has a particular genetic background which would facilitate the appearance of MAI particularly serious.