This thesis aims to contribute to the reconstruction of the sacred geography and history of the XVIIth and XVIIIth provinces of Upper Egypt commonly referred to as « Cynopolite nome » from the Ptolemaic period. Based on a diachronic analysis of the Egyptian epigraphic sources from the sacred and profane realms, its main purpose is to determine when these two provinces have merged but also to understand the role played by Hardaï, the Greek Cynopolis, in this territorial change. The examination of toponymy and local religious traditions together with a prosopographical study of individual office-holders in the XVIIth and XVIIIth provinces of Upper Egypt enable us to clarify these facts in order to better trace the eventful history of this region.