lesbian, gay and bi populations (LGB) have a poor health status compared to the general population. This inequality is explained by their health vulnerability and the indivisibility of LGB sexuality in the anamnsis. This work focuses on the latter. It analyses the relationship between the patient or patient LGB and the first appeal doctor with the aim, first, to determine the place and usefulness of sexuality and sexual orientation in the consultation of the general practitioner, second, to identify the reactions of a discussion on sexuality and sexual orientation and strategies to address these issues more easily and for the benefit of the patient, and finally to explore the representation of the general practitioner and his responsibility in the health of patients. A qualitative methodology using semi-structured interviews has been used to meet the research objectives. Five LGB individuals and five ‘gay friendly’ general practitioners were interviewed and two experts were interviewed to enrich the interpretation of the results. The results of this work indicate that, although addressing sexuality and sexual orientation is positively perceived by LGB individuals, the confrontation and harm that may arise in the patient are the main obstacles that call into question the position of these topics in the general practitioner. The practitioners interviewed do not speak about it systematically. The results also show that LGB individuals fear the doctor’s reaction to the announcement of their sexuality and sexual orientation. He and she have an ambiguous representation of the generalist, which is perceived either as a resource or as a danger to their health. LGB individuals expect a normality attitude from the doctor when talking about sexuality and sexual orientation. He and she want to be able to assert their difference without being stigmatised by the generalist. How to talk about sexuality and sexual orientation without abusing the patient? How can the general practitioner be considered a resource? This work provides some avenues for a response. Sexuality and sexual orientation affect health. As a result, these themes have their place in the anamnsis. To avoid harm, an inclusive approach that integrates all forms of sexuality and sexual orientation into the medical approach and reflection, and indirectly through projective questions, can be used. A secure and trusted framework is recommended. The language must be neutral and non-oppressive. These issues, moreover, should not be addressed either by a direct approach or by screening for sexually transmitted infections. A summary table of the various recommendations can be found at the end of the work. Finally, the general practitioner must listen to the patient and explain his/her approach. He or she must work on his representations of sexuality and sexual orientation in order to create a therapeutic link of trust necessary for proper medical care.