The implementation of hospital information systems focused on care processes has been shown to improve the quality of care, the management of resources, and the productivity. These benefits are necessary in all countries, regardless of their level of development. However, a question does arise: “Given the differences in financial, technological and human contexts, should we, in Africa, undertake a differentiated strategy to achieve these shared goals?”. The aim of our study was to develop a model adapted to the cultural and economical contexts of developing countries. Our methodology was based on the adaptation and implementation of an Open Source software. This work led to the development and validation of a model in Mali named Cinz@n. It has been implemented and tested at the Mother-Child hospital in Bamako. Beyond the software implementation, change management and the training of stakeholders have been the subject of special attention. The results of the evaluation of the functional coverage, the ergonomics of the system and user satisfaction are satisfactory. 84% of users consider that the system has improved the quality of their work, and 100% of users are willing to continue the experiment, also recommending the extension of the system to all hospital departments. The qualitative analysis of the database showed strict usage of the patient identification procedures. We conclude that Cinz@n, with an investment cost of about ten thousand euros, and a wide acceptance by users can be a model for other implementations in French Speaking Africa.