Objectives:FRD u00ae (Folate Receptor-mediated Detection) has been proposed as a reliable method to screen cervical intraepithelial neoplasia 2+ (CIN2, CIN3, and cervical cancer). This study investigates the clinical significance of FRD u00ae by comparing the accuracy of FRD u00ae with that of HPV Testing and Thinprep Cytology (TCT).Methods:From March 2019 to April 2019, 81 patients in the gynecology clinic of the Second Hospital of Jilin University received screening with FRD u00ae, TCT, and HPV examinations upon visiting the clinic. If any of the three tests provided a positive result, colposcopy was performed with biopsy being the gold standard for pathological diagnosis.ResultsThe sensitivity of FRD u00ae, TCT, and HPV in the diagnosis of cervical intraepithelial neoplasia 2+ (CIN2, CIN3, Cervical Cancer) were 72.22%, 72.22%, and 83.33% respectively. The specificity of FRD u00ae, TCT, and HPV in detection of CIN2+ was 65.07%, 60.31%, and 25.39% respectively. The accuracy of FRD u00ae, TCT, and HPV in diagnosis of CIN2+ was 66.67%, 62.96% and 38.27%. The positive predictive value (PPV) of FRD u00ae, TCT, and HPV in diagnosis of CIN2+ was 37.14%, 34.21% and 38.27% respectively, while the negative predictive value (NPV) was 89.13%, 88.37% and 84.21% respectively.Conclusions:FRD u00ae provided high values of sensitivity, specificity and accuracy. FRD u00ae has advantages in detection speed (< 60 seconds), economic cost, and patient compliance. FRD u00ae can be an effective and advantageous tool for the primary screening of cervical intraepithelial neoplasia 2+ (CIN2, CIN3, Cervical Cancer), especially in regions with hard-to-reach patients.