Written in the end of 406, the Comment on Hosea by Jerome of Stridon (c. 347-419/420) is the transition between its biblical comments on Minor and Major Prophets. Within this vast exegetical project, the work constitutes a good example of an hermeneutics well mastered. With a strong concern of coherence, the exegete displays the essentially historic literal interpretation to introduce the spiritual interpretation declined in two senses, the one anti-heretic, the other one mystic, both presented as fundamental to understand the book of Hosea. The work also constitutes a key witness to seize the importance of the typology, both centered on Jesus Christ and his Church, to explain the Prophets according to Jerome.Besides, the work was the object of no in-depth research both on its contents and on its text. So, new philological researches allowed to establish the handwritten transmission and to propose the first elements of a scientific edition of the text.