The evolution of techniques for the controlled release of active ingredients (APs) contributes significantly to human health. In this context, the development of new galenic models represents a real technological challenge. The objective of this study was the development of organosilicate (OS)-molecule bioactive complexes in order to develop new galenic models. These organosilicates were part of the patented project for the synthesis of particles similar to natural clays called EBISilc®. Indeed, the EBInnov® laboratory has developed OS particles synthesized by the sol-gel route with a previously defined ratio of starting alkoxysilanes having lipophilic (L) / hydrophilic (H) side chains with basic catalysis, in the presence of calcium (Ca2+) and aluminum (Al3+) ions.First, a proof of concept study was carried out on one of the lipophilic OS particles (OSL). The objective was to determine the capacity of OSL to adsorb a hydrophobic model molecule, benzophenone-3 (BZ-3), used as a UV-filter. The effects of the main experimental parameters on the adsorption were determined in a batch system such as the solvent, the pH, the temperature, the initial concentration of BZ-3 and the contact time. A comparative study of the adsorption capacity of OSL was carried out in comparison with a natural clay mineral, montmorillonite (MMT) and a synthetic clay, LAPONITE® (Lap). The equilibrium of the adsorption isotherm was described according to the models of Langmuir, Freundlich and Temkin as well as a study of the thermodynamic parameters. The surface adsorption of adsorbents was analyzed with empirical kinetic reaction-adsorption models of pseudo first order (PFO), pseudo second order (PSO) and Elovich model. In order to understand the mass transfer mechanism, the Weber-Morris (WM) intraparticle diffusion model and the surface diffusion model (SDM) were also studied. In order to assess the desorption capacity of the adsorbents, a comparative study of the three adsorbents (OSL, MMT and Lap) complexed with BZ-3 was explored using five desorption models, the zero-order, the first order, the Higuchi (H) model, the Hixson-Crowell (HC) model as well as the Korsmeyer-Peppas (KP) model. BZ-3 was released from the complexes continuously and homogeneously. Finally, a comparative study of the photoprotective effect of the three adsorbent-BZ3 complexes was implemented in topical sunscreen formulations