ACUTE ISCHAEMIC STROKE TREATMENT AT AORN CARDARELLI, NAPLES. A RETROSPECTIVE ANALYSIS OF THE FIRST 250 PATIENTSCandelaresi P, Alfieri G, Andreone V, Di Iorio W, Maniscalco G, Manzo V, Napolitano M, Ranieri A, Renna R, Rippa R, Servillo G, and Florio CNeurology & Stroke Unit, AORN Antonio Cardarelli, via Cardarelli 9, 80131, Naples, ItalyCorresponding author: Paolo Candelaresi, Neurology & Stroke Unit, AORN Antonio Cardarelli, via Cardarelli 9, 80131, Naples, Italy. Email: paolo.candelaresi@aocardarelli.it Phone +393484220987IntroductionThe widespread availability of acute stroke treatments has historically been patchy expecially in the South of Italy.Here we present the analysis of the first year of acute ischaemic stroke treatment at AORN Cardarelli Hospital, Naples, Italy.Materials and MethodsData regarding the first 250 consecutive patients (female 49.6%) undergone reperfusion treatments since August 2017, to December 2018. We analysed: 1) number and percentage of patients admitted to our ward treated with acute therapies; 2) pre-hospital and in-hospital delays; 3) early outcome defined as the DeltaNIHSS score between admission and discharge; 4) complications. A subgroup analysis demonstrates trends in time.Resultst2017t2018Number of treated patients t39(28.2%)t211(45.1%)IVTt29(74.3%)t116(55%)Bridgingst2(5.1%)t54(25.6%)Primary EVTt8(20.5%)t41(19.4%)Prehospital delay(IQR)t71 min(53-149)t100 min(67-142)Basal NIHSS(IQR)t14(11-16)t12(7-18)Door-to-needle time(IQR)t107(88-172)t80(59-111)Door-to-Groin time(IQR)t191(150-260)t138(117-186)Discharge NIHSS(IQR)t7(3-14)t3(0-10)Wake-up/unwitnessedt1(2.5%)t24(11.3%)Delta-NIHSS between admission and discharge was statistically significant (p<0.05). The year 2018 was divided in 4 trimesters. tJan-March tApr-June tJuly-Sept tOct-Dec tDoor-to-needlet117t87t63t78tP<0.05Door-to-Groint167t140t126t135tPnsComplications:SICHt15(6%)Fatal ICHt7(2.8%)Angioedemat1(0.5%)Arterial dissectiont1(0.9%)Arterial perforationt1(0.9%)90-days-mRS was available for 30% of patients: of them, 54.8% were independent (mRS 0-2), whereas 30% were dead. DiscussionThis analysis showed the increase in the number of patients treated with acute reperfusion therapies since August 2017. Accordingly, the in-hospital delays progressively and significantly lowered. Further lowering of in-hospital delays and patientsu2019 loss at follow-up are the coming objectives.