Other
English
ID: <
10670/1.ohszwa>
·
DOI: <
10.26226/morressier.5d89e64be90a0c423845ccdb>
Abstract
Problem statement The main problem for fetal morbidity and mortality in twenty first century is still the premature delivery. It`s very highly searched how to predict which women will give preterm labour. The most widely used method of ultrasound cervical length measurement can determine the patients at highest risks, but there is no stable cutoff. Therefor were found some clinical biomarkers in the cervico-vaginal fluid u2013 one of them is the fetal fibronectin (fFN). The aim of the study was to evaluate the predictive value of measuring the cervical length plus a quality test of fFN.MethodsA prospective, cross-sectional study was designed, dividing pregnant women between 24 and 32 weeks: Group A patients with clinical symptoms of preterm birth and Group B patients without symptoms. All patients that were included had a test of fFN performed followed by a transvaginal measurement of the cervix. The results from the fFN were blinded, all patients received same management, respectably, the patients from Group A were administrated tocolytic and steroid therapy. The pregnancy outcome was collected to be analyzed.Results63 patients took part in the research. All patients from group A that were positive on fFN and had shortening of the cervix, delivered in 2 weeks no matter the strong tocolytic. The results from Group B show false positive predictable value. The test showed high predictive value when negative result. When applying the used biochemical test in combination with cervical biometrics, the risk of preterm can be determined by more than 95% of the cases.ConclusionThe modern obstetrics cannot afford to skip the problem of the premature. Even so, the currently used methods for prediction are showing unsatisfactory predictive efficacy if used one by only. What we really need is to either find new methods for screening or improve those we have. The results from many studies are proving that the more markers are combined in one protocol, the better prognosis, the bigger the sensitivity and specificity, the best pregnancy outcomes.AcknowledgementsThis research was funded by Medical University u2013 Pleven through research project D1/ 2018.