test
Search publications, data, projects and authors

Thesis

French

ID: <

10670/1.rniac5

>

Where these data come from
Study of the cholesterol metabolism in breast cancer progression and resistance and identification of new therapeutics targets

Abstract

Breast cancer (BC) is the most frequent cancer and the leading cause of cancer death in women. Therefore, there is an urgent need to characterize the molecular players involved in the etiology of breast cancers, progression and resistance in order to develop new therapeutic alternatives to improve the prognosis of patients. The present work focuses on the study of an onco-metabolite produced from cholesterol that has been identified in the laboratory and to characterize its role and the enzymes producing and regulating this onco-metabolite. This onco-metabolite is a tumor promoter that stimulates in vivo the progression and invasiveness of different subtypes of human BC, including the most aggressive ones. The identification of this new metabolic pathway will produce news markers for BC and of the efficacy of anti-cancer compounds, as well as innovative therapeutics to counter the production of this onco-metabolite.

Your Feedback

Please give us your feedback and help us make GoTriple better.
Fill in our satisfaction questionnaire and tell us what you like about GoTriple!