Background and Goal of Study: This work is a retrospective descriptive and analytical study ofdocumented infections related to the central venous catheters, spread over a period of one year,from January 2015 to December 2015, carried out in the medical resuscitation department of the IbnRochd Hospital in Casablanca, Morocco.Materials and Methods: Included were all patients with central venous catheterization, with orwithout bacteraemia, after hospitalization in the medical resuscitation unit of Ibn Rushd Hospital formore than 48 hours.Results and Discussion: Gramnegativebacilli were isolated from the culture of central venouscatheters in 40.5% of cases. Grampositivecocci represented a rate of 35.1%, coagulasenegativestaphylococcus is the most frequently isolated with a rate of 84.61 %. Grampositivebacilli representa rate of 8.2%.Acinetobacter baumannii is found to be 26.6%, is resistant to 100% Imipenem, sensitive to Amikacin,Gentamycin, Cefepime and Netilmycin Klebsiella pneumoniae is found 26.6%, it is resistant to 75%Ampicillin and Cefotaxime, and sensitive to 75% at Imipeneme, Amikacin and Cefoxitin.For Proteus mirabilis, 50% were resistant to ampicillin, cefalotine and imipeneme.The rate of enteric bacteria producing ESBL was 62.5%. For Pseudomonas aeruginosa, 100% wereresistant to imipenem, ceftazidime, gentamycin and Netilmycin.Staphylococcus coagulase negative was resistant to Penicillin G with a rate of 72.7% and 63.6% tokanamycin with a sensitivity of 100% to teicoplanin.Conclusion(s): The main problem in intensive units are nosocomial infections .The infectionsrelated to central venous catheters are a risk and they can be due to multiresistant bacterias .In ourstudy, Acinetobacter baumanii is the main germ and it is resistant to imipenem in 100%. A strategy ofmanaging antibiotherapy is essential in intensive care so are preventive measures in nursing andcatheters cares.