Background and aims: Neuropsychological and mood disorders including fatigue, anxiety, depression and sleep disturbance are frequent symptoms encountered in people with stroke (pwS). Despite their affect on recovery and outcome, they often stay overlooked and not properly assessed. The aim of this study is to evaluate the association between the type of stroke, etiology, neuroradiological characteristics, stroke localization and patient comorbidity with the prevalence of fatigue, anxiety, depression and sleep disorders during the acute stroke period (at the time of hospital discharge) and at six month follow-up period and also to make comparison with results from age-matched healthy controls (HC).Methods: Patients aged 18 years and older, who have suffered an acute stroke are included in the study. Exclusion criteria are: dysphasia, severe cognitive impairment (MMSE18 or MADRS>6 or HADS-A >7 or Epworth >9). Charts are showing relationship between average scale values for both pwS and HC group.Conclusion: Different fatigue and depression scales showed similar trend of correlation in both pwS and HC. In the group of pwS we have found higher prevalence of depression in comparison with HC. Regarding fatigue, anxiety and sleep disorder there was no statistically significant difference between pwS and HC but a number of enrolled patients is still to small. Study is still in progress.