Aim of the study was to estimate the in-hospital mortality and death rate in patients with AMI according to gender and location of infarction during 5 years before and after the introduction of percutaneous coronary intervention (PCI) procedures in Split University Hosptial Center, Croatia. The hospitalized patients were devided in two groups, from 2000 to 2004 and from 2005 to 2009. The analysis included total mortality and mortality according to gender and location of AMI. The location of infarction was detected toward typical ECG changes. The analysis included the model of death in patients with AMI and in-hospital mortality of patients undergoing the PCI procedures. The patients in the first group were treated with the standard medication therapy, and the patients in the second group were treated with PCI. The number of hospitalized patients with AMI, in ten years, increased from 475 to 652. A total of 5339 patients with AMI were hospitalized, and included 67.5% males and 32.5% females. The first group included 2336 patients (68% males and 32% females). The second group included 2973 patients (67% males and 33% females). Male patients in average were 5 years younger than female patients. A total in-hospital mortality was significantly higher in the first group (13.5 vs. 7.6%). The mortality in the first group was significantly higher in females (22.7 vs. 12%) and in males (9 vs. 5.5%) comparing with second group. In-hospital mortality in the patients with STEMI was significantly higher in the first group (16.6 vs. 9%). Among the patients with NSTEMI there were no significantly differences in the in-hospital mortality (4 vs. 2.5%). The most frequent trigger of death in males were ventricular fibrillation in both groups such as heart failure in females. Cx occlusion is more often among the male patients treated with PCI. In-hospital mortality in patients with STEMI treated with PCI was 5.7%. A in-hospital mortality in the patients with AIM after PCI was almost halved. Females had two times higher in-hospital mortality before and after PCI introduction.