Myofascial Trigger Points (MTrPs) are source of regional pain and neuromuscular dysfunctions. They are associated to hyperalgesia, psychological disturbances and functional restrictions. Despite myofascial pain has been extensively studied, researches about its influence have only analyzed uniarticular motions. The mains goals of this research were to study the upper limb myofascial pain and to verify whether the application of manual therapy, influencing this pain, could contribute to the motor performance recovery of multiarticular motion. Four studies were carried out in order to analyze: 1) motor performance of an elliptic motion in the horizontal plane, 2) motor performance of an elliptic motion in the frontal plane including an analysis of a tapping task, 3) non-paretic upper limb pain of the stroke patients, 4) myofascial pain incidence at the medical staff in a hospital. The results showed that the presence of TrPs produces myofascial pain. This pain: 1) does not influence significantly the horizontal elliptical motions motor performance, 2) deteriorates the frontal elliptical motions motor performance and the execution of the tapping task, 3) modifies the non-paretic upper limb motor function of the stroke patients, and 4) 8,43 % of medical staff suffers from bilateral myofascial pain, leading to absence at workplace in 14,28% of the cases. The application of local ischemic compression technique allows high recovery of the upper limb motor function. Motor reprogramming therapies could contribute to recover the motor function completely.