The purpose of this study was to compare the physiological stability during and after clustered care of preterm infants between born between 24 and 316/7 weeks of gestational age and hospitalized in the Neonatal Intensive Care Unit (NICU) versus a non-clustered standard care. Ten preterm infants, between 24.2 and 29.6 weeks of gestational age at birth, were recruited for the study. The analysis of covariance with repeated measures controlling for noise showed no significant difference in SCRIP scores between the periods of clustered care and control. In light of these results, preterm infants should benefit from this intervention when hospitalized in the NICU, in order to reduce the frequency of manipulations, offer longer periods of sleep and limit their energy expenditure.