Information System (IS) investment is a major issue for the development of organizations although it also represents a significant risk, regarding the failure probability of these kinds of projects. The Human Factor is a key component of successful IS projects, and must be considered as part of the innovation process. Applied to the field of Intelligent Transport Systems (ITS), this research work does its utmost to put forward an approach to integrate human activity and its transformation at the heart of IS project management processes. The goal of this research was to provide ITS Bretagne with an intervention framework, which would enable it to diagnosis what support would be needed by an organization which is planning to integrate an ITS. The results of this diagnosis would then be used to propose an appropriate change management procedure. Intrinsically integrative, the approach created in this research is based on the operationalization of the instrumental genesis process (Rabardel, 1995) – i.e. the mutual transformation of human and technical components of an instrument – at organizational, collective and individual activity levels. It works in a transversal and continuous way, throughout the three usage analysis stages: acceptability, acceptance and appropriation. The use of this intervention framework for an experimental project, within the logistic chain of a French manufacturer, enabled us to prove its feasibility and relevance, as well as opening up new fields of research concerning its future applications and development