International audience This communication will aim to analyze the effects in terms of territorial innovation of cultural players networks rooted in urban districts. Cultural sectors workers are agents of cultural development in cities. Artists, theater directors and gallery owners participate in the creation, production and diffusion of cultural offer at different scales. The scientific literature points out a planned or spontaneous phenomenon of spatial agglomeration of these workers in specific urban neighborhoods know as artistic (Ambrosino, 2013), cultural (Mommaas, 2004) or creative (Liefooghe, 2015) quarters. The concentration of cultural workers inside urban neighborhoods encourages to question their relationship with these spaces and their ability to foster the territorial innovation. Are they developing some actions into the neighborhood scale? Are there some collective dynamics emerging between cultural players? Are there links with other stakeholders of these territories (inhabitants, local merchants…)?To answer these questions, a qualitative methodology mobilizing semi-structured interview (more than 60 interviews with cultural players and inhabitants in 2015 and 2016), mental map (Gieseking, 2013), social network analysis and observation has been used to analyze the Panier (Marseille, France) and Olivettes (Nantes, France) districts. These two central neighborhoods concentrate many associations and companies of cultural industries (see Petiteau, 2012 in the case of Olivettes). Former wastelands, these quarters now enjoy an urban and economic renewal transforming their image.The analysis of the results of field work shows that cultural players of the studied areas seeking to participate in local life by proposing a cultural offer. This cultural offer takes various forms ranging from participatory photographic workshops, to the positioning of works of art in the public space (graffiti ...), through the programming of art shows in the streets and pubs. A social network linking cultural players in each quarter emerges and allows the realization of collective projects and events whose main purpose is to animate these territories. These actions are also an opportunity to create links with inhabitants and local merchants. Based on local resources and aimed to enliven the cultural life of the territory, these actions brought by cultural players foster the territorial innovation.The presence of cultural players and their actions at the local level participate in the image evolution of the Panier and Olivettes neighborhoods. Strategies of real estate appreciation building on this evolution lead to the emergence of a process of gentrification which selects the resident population of the districts on an economic criterion. This process can question the territorial innovation driven by cultural players, improvement of welfare not benefiting the low-income populations forced to move due to rising rents and property prices.