This monograph of Casterman publishing and printing house draws the book business changes from aftermath of the Great War until globalization and editorial concentration that marked, in the end of 20th century, publishing in French language. Casterman is generally associated with the Hergé’s Aventures de Tintin publishing for which commercial and critical success overwrite a first historical analysis of one of the most important and old book company from French Community of Belgium. However, the wealth of Casterman's archives, kept now in the Belgian state archives of Tournai, allows for a global approach to the company and its editorial production. Our work portray an employer dynasty in books of remarkable longevity and sheds light on transformations of company‘s structure and productive apparatus as well as its territorial anchorage in Tournai, near the French border. In the same time, our thesis highlight the editorial catalogue inflections, from piety books release in interwar period to specialization in comic books. In 1919, the brothers Louis and Gérard Casterman arrival, representatives of fifth employer generation in the century-old family firm, matched for a new cycle of growth for the company. In 1925, contract obtainment to print the Belgian telephone directories provided a new dynamic for the printing press, while the publishing house invested children's publishing market, notably by means of Hergé's albums. The colossal success of the Aventures de Tintin after albums colorization initiated in 1942 changed the gravity centre of the catalogue. Driven by Hergé’s success, Casterman became one of the primary French-speaking publishers for children during 1950-1970 years, while maintaining a significant religious-based production with moral education books and La Revue nouvelle. In this time, the company based its growth on development simultaneous and supplementary of its editorial structure on border both sides and of its printing in Tournai. In 1978, while facing the collapse of denominational publishing and the need to renew its production, the publishing house made a singular shift leading to comic books non-conformist and intend for adults with publication of monthly (À Suivre). In last third of the twentieth century, the Casterman model of family publisher-printer was weakening by book economy changes in financial capitalism era, rapid technological changes in printing press under effect of computerization and shareholding dilution, until sale of the publishing house to French group Flammarion in 1999.