Scientific information literacy is a major concern for librarians involved in user training. At the University of Liège (Belgium), a framework has been created to map the knowledge, skills and attitudes necessary for the search, the evaluation and the use of publication from scientific research. Its purpose is to contribute to the development, improvement and even evaluation of courses and training aimed at mastering scientific information. This framework, called the “five pillars of scientific information literacy” (5PMIS), was developed on the basis of consultation of other frameworks for information literacy, the contribution of 32 teachers and researchers as well as the analysis of courses given at the University of Liège. After reviewing by internal or external members of the University of Liège, the framework was put online in September 2017. Tool for coherence and collaboration between the library-trainers of the ULiège Library, the 5PMIS covers the three knowledge sectors represented at the University, namely the human sciences, science and technology and the health sciences. It focuses on the academic context and takes into account different levels of development in the university curriculum. The objective of this article is to describe the creation of this framework, designed so that each trainer can appropriate it according to the type of audience targeted. It is not only intended for information professionals and librarians. The advantage is that it can also be mobilized in transversal approaches, by teachers from different backgrounds. Although developed for the University of Liège, the 5PMIS can thus be used and adapted by other higher education institutions, both university and non-university.