test
Search publications, data, projects and authors

Dataset

Undefined

ID: <

50|dedup_wf_001::041b98e8eda9bbf22ab5f9e259c9ca89

>

·

DOI: <

10.5061/dryad.f502p

>

Where these data come from
Data from: A nutrient mediates intraspecific competition between rodent malaria parasites in vivo

Abstract

Hosts are often infected with multiple strains of a single parasite species. Within-host competition between parasite strains can be intense and has implications for the evolution of traits that impact patient health, such as drug resistance and virulence. Yet the mechanistic basis of within-host competition is poorly understood. Here, we demonstrate that a parasite nutrient, para-aminobenzoic acid (pABA), mediates competition between a drug resistant and drug susceptible strain of the malaria parasite, Plasmodium chabaudi. We further show that increasing pABA supply to hosts infected with the resistant strain worsens disease and changes the relationship between parasite burden and pathology. Our experiments demonstrate that, even when there is profound top-down regulation (immunity), bottom-up regulation of pathogen populations can occur and that its importance may vary during an infection. The identification of resources that can be experimentally controlled opens up the opportunity to manipulate competitive interactions between parasites and hence their evolution. Dataset for Wale et al. 2017 Proc R Soc BDataset used in the paper. Includes daily measurements of red blood cell densities and the weight of mouse hosts, as well as the density of each parasite strain. Information about units of measurements given in the sheet entitled 'Notes on Data'.Waleetal_data.xls

Your Feedback

Please give us your feedback and help us make GoTriple better.
Fill in our satisfaction questionnaire and tell us what you like about GoTriple!