Intrafamilial homicide is a complex phenomenon. Most cases are related to spousal murder, filicide (murder of a child by one or both parents) and parricide (murder of either father or mother). Following epidemiological data on intrafamilial homicides by mentally disordered perpetrators, an analysis of clinical aspects shared by those pathological homicides will be presented. Finally, a detailed description of each type of the most frequent intrafamilial homicides will be provided.