Widespread niche convergence suggests that species can be organized according to functional trait combinations to create a framework analogous to a periodic table. We compiled ecological data for lizards to examine patterns of global and regional niche diversification, and used multivariate statistical approaches to develop the beginnings for a periodic table of niches. Data (50+ variables) for five major niche dimensions (habitat, diet, life history, metabolism, defense) were compiled for 134 species of lizards representing 24 of the 38 extant families. Principal Coordinates Analyses were performed on niche dimensional datasets, and species scores for the first three axes were used as input for a Principal Components Analysis to ordinate species in continuous niche space, and for a Regression Tree Analysis to separate species into discrete niche categories. 3D models facilitate exploration of species positions in relation to major gradients within the niche hypervolume. The first gradient loads on body size, foraging mode, and clutch size. The second was influenced by metabolism and terrestrial versus arboreal microhabitat. The third was influenced by activity time, life history, and diet. Natural dichotomies are activity time, foraging mode, parity mode, and habitat. Regression tree analysis identified 103 cases of extreme niche conservatism within clades and 100 convergences between clades. Extending this approach to other taxa should lead to a wider understanding of niche evolution. C1-Appendix134 lizard species with data on 50 niche dimensions including habitat, anatomy, diet, life history, metabolism, and defense. Four other variables (semi arboreal, semi fossorial, crepuscular, and mixed foraging mode) were scored with double entries. Multivariate analyses capture 61.7 % of the total variance in the first 3 dimensions. Lizard niches appear to be tightly constrained.Appendix_I.xlsx