Mentoring attracts growing interest throughout the country. The literature recognises that twinning between an experienced person (mentor) and another less experienced (mentee) is an effective means of professional development and learning of individuals. This practice is used, in particular, to relieve professional overload, integrate new employees, retain talent internally and break isolation. Mentoring can take different forms and provides benefits not only to mentee and mentor, but also to the organisation. When formally organised in a programme, there are many benefits, including the natural transfer of key knowledge and skills, the valorisation of a learning culture, better collaboration between services, improved management skills and support for diversity. After enumerating 10 conditions of success prior to the establishment of a programme, the authors present the necessary steps to put it in place in its surroundings. Mentoring is also becoming increasingly challenging, while some may be tempted to circumvent the milestones and give less rigour to the establishment of the programme. Thus, it is important to recall the importance of fostering a well-founded mentoring culture that helps to support professional development.