ORCiD ID: Costas I. Karageorghis orcid:0000-0002-9368-0759; Steffen Moritz orcid:0000-0001-8601-0143; Isgard Ohls orcid:0000-0002-3329-3116; Veena Kumari orcid:0000-0002-9635-5505. ; Copyright © 2022 The Author(s) and IAMM. In this report, we present the first case of depression showing symptomatic improvement with the auditory training program, Music for the Mind 2, added to a standard treatment regimen. This commercially available program combines advanced psychoacoustic techniques with the improvisational art of Ostad Elahi (1895–1974) to encourage active listening by targeting early auditory information processing (EAIP) pathways. We introduced MFM2 as add-on therapy to standard treatment over a 3-week period and administered the listening regimen (minimum 20 min per day) to a young Caucasian male with a first episode of major depression. We assessed the impact of MFM2 on depressive symptomatology as well as coping mechanisms and mindfulness. The results showed that through targeting EAIP pathways and thus accessing higher-order cognitive functions (e.g., active listening), recovery from depressive symptoms can be accelerated. Further studies are needed to investigate the impact of auditory training, particularly MFM2, on clinical outcomes, brain structure, and function. Through this case report, we introduce an innovative, safe, and effective music medicine that can enhance the lives of people with depression.