This doctoral thesis aims primarily at the study of heterogeneous catalysts for fine chemistry products. Thanks to the simultaneous application of advanced combinational methodologies, high-capacity experimental devices (High-Throughput technology) and fundamental material characterisation techniques, it has been possible to develop and optimise new heterogeneous catalysts in different processes of industrial interest. In particular, three lines have been investigated for the production of organic intermediates, based on carbon-carbon coupling reactions (Pd catalysts), olefins epoxidisation (titano-silicates) and cheating nitro groups hydrogenation (gold, platinum, ruthenium and nickel catalysts). Control of material properties at atomic level (supported nanoparticle chemistry) has made it possible to propose new highly active and selective catalytic systems to carry out these transformations, providing clean and efficient solutions for the sustainable production of multiple chemical compounds.