[s] Summary This doctoral thesis entitled "supramolecular chemistry: New chemical dosimeters and hybrid materials for chromo-fluorogenic detection of anions and neutral molecules. "is based on the application of basic principles of supramolecular chemistry and material science in the development of optical sensors for anions and neutral molecules. The second chapter of this doctoral thesis is dedicated to the preparation of chemical dosimeters for the detection of fluoride chromo-fluorogenic, diisopropyl fluorophosphate (DFP) and hydrogen sulphide. For the optical detection of fluoride anion, a pyridine derivative functioned with a t-butyldimethylsilyl ether was synthesised. This chapter also describes the preparation of a chemical dosimeter for the detection of PFDs, which is a simulant of nerve agents. This dosimeter is based on a stylbeno functioned with a pyridinium salt containing hydroxyl groups and silyl ether in its structure. Two sensor families were finally prepared for the optical detection of hydrogen sulphide. The first sensor family consists of common fluorophores operated with 2,4-dinitrophenyl ethers. The prepared sensors did not exhibit significant fluorescence emissions while in the presence of anion hydrogen sulphide, a significant increase was observed. The second dosimeter family was also composed of certain fluorophoros but, in this case, operated with azide and sulfonilazid groups. The prepared dosages, following this second approach, did not show significant fluorescence either, with an increase in fluorescence by adding anion hydrogen sulphide. The third chapter of this doctoral thesis is devoted to the preparation of nano-scopic hybrids operated with molecular doors and their application in recognition protocols. A material for the optical detection of gluthion (GSH) was first prepared. For this purpose, MCM-41 mesoporous nanoparticles were used as an inorganic carrier. The spores of the substrate were loaded with the colouring agent safranin O and the outer surface operated with olive (ethylene glycol) containing disulphide bonds. Several hybrid materials were also prepared and characterised for the selective detection of anion hydrogen sulphide. MCM-41 mesoporosa silica was also used as an inorganic support in this case. The pores of the inorganic support were loaded with [Ru (bipy) 3] 2 + and the external surface operated with several macrocyclic complexes of Cu (II). The final sensor material was obtained by adding anion hexametaphosphate, which complex with Cu (II) complexes, leading to a blockage of the pores.