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Article

English

ID: <

http://hdl.handle.net/10251/80515

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·

DOI: <

10.3109/02656736.2012.711894

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Where these data come from
Electrical-thermal performance of a cooled RF applicator for hepatic ablation with additional distant infusion of hypertonic saline: In vivo study and preliminary computer modeling

Abstract

Purpose: The Cool-tip electrode is one of the most widely employed applicators in radiofrequency (RF) hepatic ablation. Previous research demonstrated that it is possible to enlarge coagulation volume when the single cooled electrode is associated with distant infusion of saline (hybrid applicator). The aim of this study was to compare the electrical-thermal behaviour of the Cool-tip electrode with that of the hybrid applicator. Materials and methods: Forty-two RF ablations were performed on a total of 10 pigs: 22 with the Cool-tip electrode and 20 with the hybrid applicator (low infused saline volumetric flow rate of 6 mL/h at 2 mm distance). We compared both electrical performance (delivered power and number of roll-offs, i.e. sudden rises in impedance that interrupt the power delivery) and coagulation zone characteristics. In addition, we built a one-dimensional model to provide a basic physical explanation of the difference in performance between the different applicators. Results: The experimental results showed that the number of roll-offs with the Cool-tip electrode was higher (24.3 3.1 versus 6.7 7.0). The hybrid applicator created larger coagulation volumes (19.7 9.5 cm3 versus 9.5 5.8 cm3 ) with larger transverse diameters (2.5 0.6 versus 1.9 0.5 cm). The one-dimensional model confirmed the delay in the incidence of the first roll-off, but not the heterogeneity of the hybrid applicator’s electrical performance in the experiments. Conclusions: The hybrid applicator produces fewer roll-off episodes than the Cool-tip electrode and creates larger coagulation volumes with larger transverse diameters. This work received financial support from the Spanish Plan Nacional de I_D_i del Ministerio de Ciencia e Innovacion, grants TEC2008-01369/TEC and TEC2011-27133-C02-01. The authors thank CONACyT (Mexico) for support from project CB-2007/84618 that enabled research visits of R. Romero-Mendez to the Universidad Politecnica de Valencia (Spain) and E.J. Berjano to the Universidad Autonoma de San Luis Potosi (Mexico). The translation of this paper was funded by the Universitat Politecnica de Valencia, Spain. F. Burdio and E. Berjano declare an interest (stock ownership) in Apeiron Medical SL, a company which has a licence for the patent application US 2010/137856 A1, on which the hybrid applicator tested in this study is based. The other authors have no conflict of interests or financial ties to disclose. The authors alone are responsible for the content and writing of the paper. Romero-Méndez, R.; Tobajas, P.; Burdío Pinilla, F.; González, A.; Navarro Gonzalo, A.; Grande, L.; Berjano, E. (2012). Electrical-thermal performance of a cooled RF applicator for hepatic ablation with additional distant infusion of hypertonic saline: In vivo study and preliminary computer modeling. International Journal of Hyperthermia. 28(7):653-662. https://doi.org/10.3109/02656736.2012.711894

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