For downloading the full-text of this article please click here. Background and Objectives: Addiction and drug abuse as a social problem disrupt the social ability to retain the order and organization, thus the normal social life is impaired which causes structural changes in the economic, social, political and cultural systems of a society . The aim of this study was to investigate the efficacy of religious, spiritual and mental therapy on  stress reduction, anxiety and depression in women with addicted spouse in Ilam city. Materials and Methods: This research was experimental study with pre, post test and control groups and follow-up period. Research population included 45 women with addicted wife who were selected by convenience sampling. Hamilton and Beck test were used to evaluate stress and depression, respectively. Results: Results of ANOVA revealed a significant difference in the level of stress and depression (p<0/001) between the experimental and control groups. Conclusion: The results revealed behavior therapy based on religion has a significant effect on reduction of the amount of stress and depression in women with addicted spouse. As regards to the role of religion and Spirituality in the process of recovery, addressing the concept of spirituality is essential stress reduction and depression. Keywords:  Mental health, Spiritual-religious efficacy, Stress, Anxiety For downloading the full-text of this article please click here.