This study aims to provide valuable insights into the process of innovation for development. We selected the “Reinvent the Toilet Challenge”, an initiative of the Gates Foundation, with the objective of creating sustainable sanitation solutions for the 2.5 billion people across the globe who lack access to safe and affordable sanitation. The Naturally Acceptable and Technologically Sustainable (NATS) team at the Asian Institute of Technology (AIT), Thailand was appointed by the Gates Foundation to serve as an innovative fecal sludge management (FSM) hub in Southeast Asia and collaborate with other researchers in the region, as well as with other teams from around the world to develop innovative FSM techniques that can help to solve the world sanitation problem. By gaining insights into how innovators interact with key stakeholders, we can understand the process of innovation for development and the role of innovation brokers in the innovation process, and then suggest a roadmap from the perspective of responsible research and innovation (RRI) to guide innovators, project leaders, industry partners, local government, and policy makers in the process of innovation for development.