We present the results of an assessment of ice surface elevation measurements from NASA's Ice, Cloud, and land Elevation Satellite-2 (ICESat-2) along the CHINARE (CHINese Antarctic Research Expedition) route near the Amery Ice Shelf in East Antarctica. The validation campaign was designed and implemented in cooperation with the 36th CHINARE Antarctic expedition from December 2019 to February 2020. The assessment of the ICESat-2 geolocated photon product (ATL03) and land ice elevation product (ATL06) was performed based on coordinated multi-sensor observations using two roof-mounted kinematic global navigation satellite system (GNSS) receivers, two line arrays of corner cube retroreflectors (CCRs), two sets of retroreflective target sheets (RTSs), and two unmanned aerial vehicles (UAVs) with cameras. This systematic validation of the ICESat-2 data covered a variety of Antarctic ice surface conditions along the 520 km traverse from the coastal Zhongshan Station to the inland Taishan Station. This comprehensive investigation is complementary to the 750 km traverse validation of flat inland Antarctica containing a 300 km latitude traverse of 88∘ S by the mission team (Brunt et al., 2021). Overall, the validation results show that the elevation of the ATL06 ice surface points is accurate to 1.5 cm with a precision of 9.1 cm along the 520 km CHINARE route. The elevation of the ATL03 photons has an offset of 2.1 cm from a GNSS-surveyed CCR and is accurate to 2.5 cm with a precision of 2.7 cm as estimated by using RTSs. The validation results demonstrate that the estimated ICESat-2 elevations are accurate to 1.5–2.5 cm in this East Antarctic region, which shows the potential of the data products for eliminating mission biases by overcoming the uncertainties in the estimation of mass balance in East Antarctica. It should be emphasized that the results based on the CCR and RTS techniques can be improved by further aggregation of observation opportunities for a more robust assessment. The developed validation methodology and sensor system can be applied for continuous assessment of ICESat-2 data, especially for calibration against potential degradation of the elevation measurements during the later operation period.