This text discusses experiences of prejudice and discrimination against transgender women and black crossings and their strategies for dealing with them. This is a descriptive qualitative study with five participants aged 25 to 47. The results showed that the increased vulnerability to violence of transgender women and black crossings stems from experiences of prejudice and racial and sexual discrimination, causing them to be hampered by their transition from gênero and preventing them from fully living the identities they have assumed for themselves. Religious affiliation and participation in self-organised groups are their main strategies for tackling self-esteem, developing experiences of prejudice and discrimination and exploring their possibilities of femininity freely. The creation or upscaling of policies that can fully support the health of transgender and crossing women is key to promoting the well-being of that population and reducing their vulnerability to violence.