Bisphenol A (BPA) is a kind of environmental endocrine disrupting substance, which has been used as an organic chemical as unsaturated polyester resin. The degradation of BPA includes biological methods, physical adsorption and chemical oxidation, all which have their own disadvantages. Owing to its strong oxidization capability and stable treatment performance, Fenton process can degrade organic substances at a high reactive rate and stably effective. In this paper, Fenton oxidation method was optimized to remove BPA in water, during which the intermediate products were analysed to examine its degradation path. The optimal conditions of degradation of BPA by Fenton method were a ratio of C (H2O2)/C (Fe2+) of 10, a pH of 3.5, and the degradation rate increased with the increasing of reaction temperature. It was found that Fenton could break the chemical bond at the junction of BPA and isopropyl group to produce p-diphenol, phenol, isopropyl phenol and other intermediate products.