This study examined whether the association between sexual minority status and psychological distress is different between Black adults and White adults. The intersectionality framework suggests that Black sexual minority adults are more likely to report psychological distress than White sexual minority adults. Using data from the 2013–2017 National Health Interview Survey, multinomial logistic regression was conducted to examine the associations among race, sexual orientation identity, and psychological distress in a large representative U.S. sample that included a large number of Black sexual minority adults and White sexual minority adults. Results indicated that the association between sexual minority status and psychological distress was not significantly different between Black adults and White adults. Future research should examine resources that may buffer risk for psychological distress among Black sexual minority adults.