Vertical and horizontal transport mechanisms for marine oil spills are investigated using numerical model simulations. To realistically resolve the 3-D development of a spill on the ocean surface and in the water column, recently published parameterizations for the vertical mixing of oil spills are implemented in the open-source trajectory framework OpenDrift (https://doi.org/10.5281/zenodo.1300358, last access: 7 April 2018). The parameterizations include the wave entrainment of oil, two alternative formulations for the droplet size spectra, and turbulent mixing. The performance of the integrated oil spill model is evaluated by comparing model simulations with airborne observations of an oil slick. The results show that an accurate description of a chain of physical processes, in particular vertical mixing and oil weathering, is needed to represent the horizontal spreading of the oil spill. Using ensembles of simulations of hypothetic oil spills, the general drift behavior of an oil spill during the first 10 days after initial spillage is evaluated in relation to how vertical processes control the horizontal transport. Transport of oil between the surface slick and the water column is identified as a crucial component affecting the horizontal transport of oil spills. The vertical processes are shown to control differences in the drift of various types of oil and in various weather conditions.