The aim of this study is to validate the Italian version of the Valencia Eustress-Distress Appraisal Scale (VEDAS). Two hundred and thirty-two Italian workers were involved in the study. Dimensionality, reliability, and concurrent validity were analyzed. Confirmatory factor analysis supported a four-dimensional structure. In addition, the Italian version of the scale showed good internal consistency and validity. The results indicate that the Italian version of the VEDAS is a valid instrument for measuring eustress and distress appraisal in the Italian context.