The IT revolution and globalisation are redefining the spectrum of development opportunities for countries and SMEs. The article discusses seven major changes to take advantage of: the segmentation of markets with multiple small niches, the monopolisation practices of global corporations, the networking of clusters, the ‘glocalisation’, the coexistence of advanced and traditional technologies, the new conditions for access to the market in small quantities and the environmental problem as a criterion for innovation. This new context opens up a possible vision of Latin America’s development focusing on the ‘technogisation’ of natural resources and process industries (given that Asian countries have specialised in manufacturing). This would go hand in hand with the development of multiple local businesses to generate wealth in each corner of the territory. However, traditional support for SMEs must take into account the emergence of epiCS (small knowledge-intensive businesses), the increasing importance of which as service providers for the rest of the production system must be taken into account in development and support policies. To this end, their particularities and differences with traditional SMEs need to be understood in order to be able to design policies that suit each other. The article illustrates how technological changes are taken into account and how they make development opportunities an essential mobile target for successful policy design.