Caring children with cerebral palsy might rise the potential of having physical, emotional, and psychological burdens for the mother. Mindfulness-based interventions can help to decrease psychological distress, sleep disturbances, and physical fatigue by improving the growth of quality of life and spirituality. The purpose of this study is to discover the effect of a mindful parenting program in reducing the psychological burden of the mother’s children with cerebral palsy. This research uses the one-group pre-test post-test design using a double pre-test. Measurement of psychological burden using psychological burden scale. The participants are 6 mothers of the cerebral palsy children who followed 8 sessions mindful parenting program. Hypothesis testing using the Wilcoxon-signed-rank test along with qualitative data analysis using observation and self-report. The results showed that mindful parenting program significantly decreased psychological burden on mothers with cerebral palsy children with z = -2.201 (p = 0,028; p <0,05). The effect of a mindful parenting program on psychological burden reduction was 63% (r = -0.63).