One of the observable consequences of social and cultural change among the Huaorani, the Amerindian people of the Ecuadorian Amazon contacted in the late 50s, has been suicide, which has grown alarmingly since the beginning of the 21st century. This article focuses monographically on the case of EPAA, a 28-year-old woman, who unexpectedly and without apparent motives lost her life, leaving many unhappy. The ethnographic field work on which this investigation is based lasted for two months. On the basis of the data produced, this report provides a brief approach to Huaorani suicide in the Toñabari area and then addresses its two central objectives: (1) describe in detail EPAA suicide along with the versions of triggers; and (2) thinking from a cultural point of view on the profound factors that help to understand the behaviour of the actor. The conclusions highlight the practical meaning of chamanism as an explanation and the possible influence of the word as an element of contagion.