Subcutive-nodules are reported in tadpoles and bull frogs, Rana Catesbeiana, in the State of São Paulo, Brazil. Initially, high tadpole mortality was observed in the early stages of metamorphose and then in young imags and frogs. The tadpoles had subcutive-nodular formations at the tail and lower portion of the head and young frogs, the same type of head formation. The nodules were spherical, yellowish, encapsulated, unique or grouped, measuring between 2 and 3 mm diium-metre and with dense content. Histopathological examination highlighted in the formation a large deposit of calcium salts. There was no compromise of the peripheral muscle tissue and the formation of abscesses was not characterised by the absence of inflammatory cells. The bacteriological examination of the nodular content and the liver showed the presence of Streptococcus spp; Corynebacterium spp, Citrobacter freundii and Aeromonas hydrophila. The search for resistant alcohol-acid beakers was negative. Irritative metabolic origin is raised as a result of an infectious process.