In 2015, the National Network of Gender Equality in Higher Education Institutions agreed to establish gender mainstreaming and institutionalisation, a context relevant for the purpose of this article to analyse the composition of the school enrolment at the level of university degree at the Autonomous University of San Luis Potosi by sex. To this end, a descriptive and gender-sensitive statistical analysis was carried out, using the data obtained in the institutional yearbooks for the school periods 2004-2005 to 2013-2014. The results show that, in the composition of the enrolment, the number of women has steadily increased. It is also noted that the gender gap is more marked in schools and faculties in the capital of San Luis Potosi, where there is more female presence than in the rest of university campuses. The proportion of women in exact science and technology careers is higher than that of men in socio-administrative careers. The integration of women into hybrid careers is equal or higher than that of men.