With the continuous improvement of spiritual and cultural needs, the main reason why people are keen on traveling is that they want to learn about the cultural deposits of the scenic spots. Under this context, this paper takes the signage and wayfinding System of historical blocks as the research object, emphasizes the necessity of extracting urban cultural information and applying it to the signage and wayfinding system design, analyzes the problems existing in the signage and wayfinding system of historical blocks and the application value of urban culture in the signage and wayfinding system of historical blocks. Finally, from the perspective of urban culture, this paper puts forward a suggestion that the design of signage and wayfinding system of historical blocks shall take the characteristics of local buildings, regional styles and folk culture elements as the introduction points.