The article presents the results of experimental studies to determine the effect of antioxidant drugs “Butofan” and “E-selenium” on veterinary and sanitary parameters of cows’ milk obtained in the period after calving. Childbirth is characterized by a stressful physiological state of the body and a large amount of lipid peroxidation (LPO) products are formed in the blood of cows, which have a negative depleting effect on the body and, naturally, on the quality of milk, since it is a blood product. To enhance the work of the body’s own antioxidant system, since it is not always enough to neutralize LPO products, antioxidant drugs are used. It is necessary to determine veterinary and sanitary parameters in milk obtained under the influence of any drugs, since it is used in human nutrition. For this purpose, experimental studies were carried out on analogous dairy cows in one of the farms of Ryazan region. The cows were divided into three groups: the control and two experimental ones. The control group of animals was intact, the cows of the experimental groups received antioxidant preparations: the first one got “E-selenium” and the second one got “Butofan”. The research results showed that the milk yield of cows in the experimental groups was higher compared to the control. The quality parameters of milk in the experimental groups of cows were better in terms of fat content, protein content, density and acidity. Cow’s milk under the influence of antioxidant drugs was biologically complete and environmentally friendly.