This article explores the epistemic connotations of Buen Vivir, one of whose main characteristics is the relationship, and deepens the main feature that denies it: disciplinarity. From the perspective of (inter) cultural studies, he faces the input of Lewis R. Gordon and Martin Nakata to investigate the consequences of disciplinarity on the existence of indigenous peoples and the African diaspora, and its possible implications for higher education. Gordon shows how the nexus of living thought links the ontological, epistemological, teleological and actional aspects, which make it possible for black peoples to exist and resurgence, a link that is hidden by disciplinary decline. On the other hand, on the basis of the concept of a cultural interface, Nakata highlights the consequences of the inclusion of disciplinary knowledge on indigenous melanesian peoples in order to deny that they are active, constantly changing and taking a position in the face of coloniality. The article culminates in José E. Juncosa University of Salesiana Polytechnic jjuncosa@ups.edu.ec, discussing two proposals seeking to overcome academic discipline: inter- and transdisciplinarity (Edgar Morin), and epistetic (Roman de la Campa). Finally, it repeats some of the characteristics of the University of Buen Vivir, which is not disciplinary and necessarily intercultural and interepistaemic.