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One-electron reduction of 6-hydroxydopamine quinone is essential in 6-hydroxydopamine neurotoxicity ; NEUROTOXICITY RESEARCH ; NEUROTOX RES
3 ; FONDECYT ; jsegura@med.uchile.cl ; 1 ; FONDECYT ; 24
Depletion of brain noradrenaline and dopamine by 6‐hydroxydopamine
Summary 10 After intracisternal administration, 6-hydroxydopamine had a greater effect on brain noradrenaline than on dopamine. 2) Administration of two doses of 6-hydroxydopamine increased the depletion of noradrenaline but not of dopamine. 3) Small doses of 6‐hydroxydopamine decreased the concentr...
Time-course gait analysis of hemiparkinsonian rats following 6-hydroxydopamine lesion
Effects of 6-hydroxydopamine on visual deprivation in the kitten striate cortex
We tested the effects of 6-hydroxydopamine (6-OHDA) on two forms of visual deprivation--monocular and directional deprivation. In normal kittens monocular deprivation leads to a change in the ocular dominance histogram recorded from the visual cortex, and directional deprivation leads to a change in...
Sensorimotor assessment of the unilateral 6-hydroxydopamine mouse model of Parkinson's disease
Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by marked impairments in motor function caused by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNc). Animal models of PD have traditionally been based on toxins, such...
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Electroacupuncture Alleviates Depressive-Like Symptoms and Modulates BDNF Signaling in 6-Hydroxydopamine Rats
Previous studies have identified the beneficial effects of electroacupuncture (EA) on motor behaviors in Parkinson’s disease (PD). However, the role and potential mechanisms of EA in PD-associated depression remain unclear. In the present study, a rat model of PD with unilateral 6-hydroxydopamine (6...
Cellular studies of sympathetic denervation produced by 6-hydroxydopamine in the vas deferens.
Cellular studies of sympathetic denervation produced by 6-hydroxydopamine in the vas deferens.
Animal Model of Parkinson Disease: Neuroinflammation and Apoptosis in the 6-Hydroxydopamine-Induced Model
6-Hydroxydopamine (6-OHDA), a synthetic neurotoxin, has been used to generate animal models of Parkinson’s disease (PD). Even though 6-OHDA induced neurodegenerative model in rat, it does not reproduce all the symptoms of the disease, but it does replicate most of the cellular processes such as oxid...
The effect of the 6-hydroxydopamine induced nigrostriatal pathway degeneration on cortical glutamatergic neurons
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β-Cells Different Vulnerability to the Parkinsonian Neurotoxins Rotenone, 1-Methyl-4-phenylpyridinium (MPP + ) and 6-Hydroxydopamine (6-OHDA)
Neurotoxins such as rotenone, 1-methyl-4-phenylpyridinium (MPP + ) and 6-hydroxydopamine (6-OHDA) are well known for their high toxicity on dopaminergic neurons and are associated with Parkinson’s disease (PD) in murine models and humans. In addition, PD patients often have glucose intolerance and m...
Factors affecting the neurotoxic effects of 6-hydroxydopamine in an animal model of Parkinson's disease
Sham transplantation protects against 6-hydroxydopamine-induced dopaminergic toxicity in rats: behavioral and morphological evidence.
Administration of the neurotoxin 6-hydroxydopamine (6-OHDA) to rat brain causes biochemical and neuroanatomical changes to the nigrostriatal dopaminergic pathway similar to those observed in Parkinson's disease (PD). Although the cause of PD is unknown, it has been hypothesized that the neurodegener...
Dietary restriction does not prevent nigrostriatal degeneration in the 6-hydroxydopamine model of Parkinson's disease
Table_1_Longitudinal assessment of motor function following the unilateral intrastriatal 6-hydroxydopamine lesion model in mice.XLSX
Introduction Despite the widespread use of the unilateral striatal 6-hydroxydopamine (6-OHDA) lesion model in mice in recent years, the stability of behavioral deficits in the 6-OHDA striatal mouse model over time is not yet clear, raising concerns about using this model to evaluate a compound’s lon...
Longitudinal assessment of motor function following the unilateral intrastriatal 6-hydroxydopamine lesion model in mice
IntroductionDespite the widespread use of the unilateral striatal 6-hydroxydopamine (6-OHDA) lesion model in mice in recent years, the stability of behavioral deficits in the 6-OHDA striatal mouse model over time is not yet clear, raising concerns about using this model to evaluate a compound’s long...
Synaptic zinc contributes to motor and cognitive deficits in 6-hydroxydopamine mouse models of Parkinson's disease
International audience Hyperactivity of glutamatergic corticostrial pathways is recognized as a key pathophysiological mechanism contributing to development of PD symptoms and dopaminergic neurotoxicity. Subset of corticostriatal projection neurons uses Zn2+ as a co-transmitter alongside glutamate,...
Cognitive-Enhancing Effect of Quercetin in a Rat Model of Parkinson's Disease Induced by 6-Hydroxydopamine
Oxidative stress has been reported to induce cognitive impairment in Parkinson's disease. This paper aimed to determine the effect of quercetin, a substance possessing antioxidant activity, on the cognitive function in a rat model of Parkinson's disease. Male Wistar rats, weighing 200–250 g, were or...
Catecholamines and conditioned blocking: effects of ventral tegmental, septal and frontal 6-hydroxydopamine lesions in rats
Introduction: The performance of rats on the conditioned blocking test (CB) of learned inattention was measured in a two-way shuttle avoidance task after sham and dopamine (DA) - depleting lesions of the frontal cortex, the limbic septum, and the ventral tegmental area (VTA - A10). Methods: Animals...
Catecholamines and conditioned blocking: effects of ventral tegmental, septal and frontal 6-hydroxydopamine lesions in rats
Introduction: The performance of rats on the conditioned blocking test (CB) of learned inattention was measured in a two-way shuttle avoidance task after sham and dopamine (DA) - depleting lesions of the frontal cortex, the limbic septum, and the ventral tegmental area (VTA - A10). Methods: Animals...
Benserazide dosing regimen affects the response to L-3,4-dihydroxyphenylalanine in the 6-hydroxydopamine-lesioned rat
Peripheral aromatic amino acid decarboxylase (AADC) inhibitors, such as benserazide, are routinely used to potentiate the effects of L-3,4-dihydroxyphenylalanine (L-DOPA) in Parkinson's disease (PD) and in experimental models of PD. However, there is little information available on the optimal dose...
Neuroinflammation et neuroprotection dans un modèle de maladie de Parkinson précoce (lésion à la 6-hydroxydopamine chez le rat)
Les stratégies thérapeutiques mises en place dans la maladie de Parkinson sont symptomatiques et ne permettent pas de ralentir la progression de la maladie, nécessitant le développement de nouvelles approches neuroprotectrices. La neuroinflammation joue un rôle majeur dans le processus neurodégénéra...
The dosage of curcumin to alleviate movement symptoms in a 6-hydroxydopamine-induced Parkinson's disease rat model
Background: Curcumin is a natural compound with extensive pharmacological effects. This research is to verify the optimal dose and administration duration efficacy of curcumin in alleviating the movement symptoms of Parkinson's disease (PD). Methods: Wistar rats were divided into six groups includin...
Neuroprotection of microglial conditioned medium on 6-hydroxydopamine-induced neuronal death: role of transforming growth factor beta2
Microglia, the immune cells of the CNS, play essential roles in both physiological and pathological brain states. Here we have used an in vitro model to demonstrate neuroprotection of a 48 h-microglial conditioned medium (MCM) towards cerebellar granule neurons (CGNs) challenged with the neurotoxin...
Effects of Intracortical Infusion of 6-Hydroxydopamine on the Response of Kitten Visual Cortex to Monocular Deprivation.
Between 4 and 10 weeks of age 10 normally reared kittens were bilaterally implanted with osmotic minipumps. The visual cortex of one cortical hemisphere was infused with 4 mM 6-hydroxydopamine while the other hemisphere received only a vehicle solution. The pumps delivered the solutions at 1 microli...
Neuroprotective effects of insulin-like growth factor-2 in 6-hydroxydopamine-induced cellular and mouse models of Parkinson’s disease
Skin-derived precursor Schwann cells have been reported to play a protective role in the central nervous system. The neuroprotective effects of skin-derived precursor Schwann cells may be attributable to the release of growth factors that nourish host cells. In this study, we first established a cel...